IDEAL

CENTER FOR ANIMAL STUDIES

Preclinical (animal) Studies

We are specialized in providing our customers with assistance in disease areas of central nervous system with proven track record. We perform all metabolism studies necessary to characterise the absorbtion, tissue distribution and depletion, metabolism and elimination profiles in vivo and PK screening, as well as PK or toxicokinetic profiling, mass balance and distribution studies. Metabolite profiling and identification provides a rationale for the selection of animal.

Behavioural Models

·         Elevated plus maze

·         Light dark box

·         Y-Maze

·         T-Maze

·         Hole Board

·         Actophotometer

·         Vogels conflict anxiometer

·         Despair test apparatus

·         Chemical and electrically induced convulsions

·         Rotarod

·         Conditioned place preference

·         Plethysmometer

·         Pole climbing apparatus

·         Passive avoidance apparatus

·         Morris water mazes for rats/mice

Surgical Models:

·         Stereotaxic apparatus

·         Descrete brain lesioning studies

·         Bulbectomy, adrenelctomy/orchidectomy

·         Brain Microdialysis

·         Brain Imaging

·         Histopathology

·         Spinal cord injury

Biochemical analysis

·         HPLC (PDA and Flurescent Detectors)

·         Autoanalyser

·         Brain biochemical analysis

·         Blood/plasma determination

Animal Species:

·         Rats: Sprague-Dawley, Wistar Albino

·         Mice: Swiss Albino

·         Rabbit: New Zealand

·         Hamster:  Golden (Syrian)

Investigatory areas covered:

·         Biological Screening

·         Metabolism in vitro and in vivo

·         Bioavailability and bioequivalence

·         Drug-drug interactions

·         Diet-induced disease models

Screening CNS activities

·         Depression

·         Anxiety

·         Epilepsy

·         Parkinson’s disease

·         Alzheimer’s disease

·         Learning and memory

·         Schizophrenia (Psychosis)

·         Addiction

·         Cancer